Six years ago, researchers described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. However, the mechanism for its secretion from the bacterium was unknown. Now, ...

Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...

Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

Many pathogenic bacteria use special secretion systems to deliver toxic proteins into host cells. Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have determined the structure of a ...

Researchers at McMaster University have discovered a molecular “barcode” system used by disease-causing bacteria to distinguish between beneficial and toxic molecules. Published in the Proceedings of ...

The type III secretion system (T3SS) is a sophisticated molecular apparatus that many Gram‐negative bacterial pathogens deploy to inject effector proteins directly into host cells. This machinery ...

You suddenly feel sick -- pathogenic bacteria have managed to colonize and spread in your body! The weapons they use for their invasion are harmful toxins that target the host's defense mechanisms and ...

Bacteria have complex molecular machines that help them drive disease. Scientists can now leverage these machines to treat disease instead. It is nice to deliver drugs where you exactly want them, ...