Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...

Researchers at Umeå University in Sweden published a study “Breaking barriers: pCF10 type 4 secretion system relies on a self-regulating muramidase to modulate the cell wall” in mBIO that describes ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

Bacteria have complex molecular machines that help them drive disease. Scientists can now leverage these machines to treat disease instead. It is nice to deliver drugs where you exactly want them, ...

This discovery validates siderophore secretion as a drug target in tuberculosis and reveals a new mechanism for putative drugs. Many tuberculosis bacteria are highly resistant to multiple antibiotics.

The surfaces of Gram-negative bacteria are adorned with versatile nanomachines that include Type IV pili and associated secretion systems. These structures are crucial for a range of functions such as ...

Researchers at McMaster University have discovered a molecular "barcode" system used by disease-causing bacteria to distinguish between beneficial and toxic molecules. Published in the Proceedings of ...