The DNA damage response (DDR) constitutes a multifaceted network of sensors, transducers and effectors that preserves genome integrity by detecting and repairing lesions arising from endogenous ...

T cells lie at the heart of adaptive immunity, recognising peptide antigens via the T cell receptor (TCR) and undergoing activation only when signals from co-stimulatory receptors complement antigen ...

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages ...