Although it also performs some functions in men, estrogen, the main female sex hormone, is involved in a myriad of processes, ...

Estrogen is known as an important hormone, and it can control many functions by regulating the activity of hundreds of genes.

Researchers at the CNIO show that oestrogens regulate gene expression by changing DNA supercoiling. Hormone-activated topoisomerases reshape DNA topology, altering 3D genome organization and enabling ...

Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial ...

Understanding the dynamic behavior of DNA remains an important challenge to biophysics, in particular the folding and stretching of DNA is critical since protein-DNA interactions require that the ...

Research chemists have a found a class of synthetic molecules that could quite literally act as a key which could lock away sections of DNA into a closely wound coil preventing proteins from ...