aProximate TM PTCs maintain high expression of key transporters involved in drug handling, including megalin and cubilin, making them ideal for studying drug transporters and drug interactions with ...

New Tool Sheds Light on the Role of BCRP Protein in Drug-Drug Interactions Researchers must now take a serious look at drug transporter proteins because of a 2006 FDA draft guidance document: Guidance ...

While new drug molecules are typically tested in vivo in two preclinical species to better understand how they are transported and eliminated by the kidney and assess the risk of renal toxicity in ...

Scientists at St. Jude Children’s Research Hospital have drawn on structural biology expertise to determine structures of vesicular monoamine transporter 2 (VMAT2), a key component of neuronal ...

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty acids, and nucleotides. To date, ...