Many cancers involve upregulation of Aurora kinase B, which helps deregulate normal cell cycling to drive tumor proliferation. The kinase should therefore be a good therapeutic target, yet no ...

Researchers have identified serine threonine kinase 10 as a key regulator of platelet function, haemostasis and ...

In the pharmaceutical discovery process, understanding a drug’s residence time—the duration a molecule remains bound to its ...

This Research Topic is part of the series of "Hepatocellular Carcinoma: Novel Treatment Strategies":Hepatocellular Carcinoma: Novel Treatment Strategies - ...

46 new molecular entities cleared the agency’s hurdles last year, 4 fewer than in 2024 ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...