During B and T lymphocyte development, antigen receptor diversity arises through V(D)J recombination, a process driven by the RAG1/2 endonuclease that introduces programmed double-stranded DNA breaks ...
Lymphocyte development relies on the deliberate induction and precise repair of DNA double-strand breaks (DSBs) to generate the diverse repertoire of antigen receptors that underpin adaptive immunity.
Effect of BL-8040, high-affinity CXCR4 antagonist, on T-cell infiltration, tumor growth, and synergy with immunomodulatory agents. This is an ASCO Meeting Abstract from the 2017 ASCO Annual Meeting I.
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