Each pick has a confidence level of 1-10, with 10 being the most confident. For more information on the pick methodology, check out the Week 1 edition of this series. Keep in mind that since the idea here is to make high-percentage plays,

On the Eagles' end, their weakness has been turnovers. Philadelphia has four games this year with two or more turnovers and the Eagles have gone 0-4 in those games. If any defense out there can take advantage of that, it's a Bills unit that has forced 20 turnovers this year, which ranks in the top eight in the NFL.

Lions also kicks off at 4:25. For Philadelphia to secure the 2-seed in the NFC, they need to win and have Chicago lose.

The Arizona Cardinals lost their eighth consecutive game on Sunday, falling 37-14 to the Cincinnati Bengals on the road. They fell behind 13-0 and then, after scoring a touchdown, allowed 24 unanswered points before a garbage-time touchdown in the fourth quarter.