Eukaryotic mRNA transcription initiation is directed by the formation of the megadalton-sized preinitiation complex (PIC). After PIC formation, double-stranded DNA (dsDNA) is unwound to form a ...
Transcription of protein-coding genes begins with the formation of a pre-initiation complex (PIC) on promoter DNA 1. The PIC consists of RNA polymerase (Pol) II and the transcription factors TFIIA, ...
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