In proteomics applications of tandem mass spectrometry (MS/MS), one of the core analysis challenges is the de novo sequencing problem: given an observed fragmentation spectrum, can we infer the amino ...

In just a few decades, DNA sequencing technologies evolved from slow, manual processes to rapid, automated ones, making ...

Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...

Despite advances in mass spectrometry and emerging single-molecule approaches, sequencing peptides at the single-molecule level remains a central challenge in proteomics. Here we present a ‘reverse ...

Researchers have developed a cutting-edge technique that uses RNA “barcodes” to map how neurons connect, capturing thousands of links with single-synapse precision. The method transforms brain mapping ...

Whether you’re interested in why a living system works as it does or the reasons it goes awry, proteins are a critical part of the molecular picture. The proteins circulating in a person’s plasma can ...