Yesterday’s article by Geoff Cumming, based on a very recent Proceedings of the National Academy of Science paper, argued that “null hypothesis significance tests” (NHST) are flawed – and he is ...

Significance testing, with appropriate multiple testing correction, is currently the most convenient method for summarizing the evidence for association between a disease and a genetic variant.

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The practice of null hypothesis testing has traditionally been used to interpret the results of studies in a wide variety of scientific fields. Briefly, significance testing involves the calculation ...

For more than 40 years, null-hypothesis significance testing and P values have been questioned by statistical commentators, their utility criticized on philosophical and practical grounds 1. Luckily, ...

What to do with significance testing, the bench scientist’s statistical workhorse? Short of tossing it out once and for all, there are proposals to toughen conventional practice. These proposals seek ...

Please provide your email address to receive an email when new articles are posted on . Search engines and chatbots are easy to use. Databases such as gnomAD and ClinVar are comprehensive but come ...