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The ONE time we use Oral Vancomycin! We associate Vancomycin with IV infusions for MRSA. But for Clostridium difficile (C. diff) colitis, the rules flip. 馃攧 Why Oral? Vancomycin has poor oral bioavailability. It is not absorbed into the bloodstream. For Systemic Infections: This is bad (useless orally). For C. diff Colitis: This is PERFECT! The drug stays in the gut lumen, achieving high local concentrations exactly where the bacteria are. Why NOT IV? IV Vancomycin does not secrete well into the
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