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En el diagnóstico de la infección tuberculosa latente, la prueba de Mantoux emplea el Derivado Proteico Purificado o PPD. Su administración es estrictamente intradérmica en la cara anterior del antebrazo. El fundamento inmunológico radica en provocar una reacción de hipersensibilidad retardada tipo IV, mediada por linfocitos T de memoria frente a los antígenos de Mycobacterium tuberculosis. La evaluación clínica exige su lectura a las 48 o 72 horas post-inoculación, midiendo exclusivamente la in
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