Causes of Inflammation in Fibromyalgia The exact cause of fibromyalgia is unknown, but it is linked to inflammation, particularly neuroinflammation, triggered by a combination of genetic predisposition, central sensitization, and external factors like stress, infections, and physical trauma. These triggers can activate the body's immune system and stress response, leading to the development or worsening of the condition through mechanisms like the gut-brain axis and an altered inflammatory respo

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